American Academy of Allergy and Immunology

American Academy of Allergy and Immunology

American Academy of Allergy and Immunology March 1995 Annual Meeting

LGH Koren, E Janssen, A Willemse, DVM, PhD, Eindhoven & Utrecht, Netherlands

Many cat allergics persist in keeping cats. Attempts to reduce cat allergen (Fel d1) exposure in dwellings
include the use of air cleaners, vacuum cleaners and frequent washings. None of these methods are completely
effective and practical for everyday use. A more feasible way to reduce Fel d1 exposure was developed by the Allerpet Company.
In this study we have tested the efficacy of this measure in a furnished laboratory room. Fel d1 content was measured on
the cats’ fur, in the air and in the settled dust. Fel d I assessments by monoclonal ELISA and RAST were influence by the
presence of Allerpet. Polyclonal RIA’s appeared reliable. Extractable Fel d1 from the cat’s fur after two treatments
decreased in all cases. The Fel d1 content of dust from the carpeting on which three cats had lived for 2 weeks was
compared to carpet dust where the same cats lived on before treatment. Each of two series of tests showed a reduction
in Fel d1 of approximately 50% (20*103 to 60*103 Fel d1 in respectively 100 to 150 g dust) as compared to the untreated
versions. Air samplings using an Anderson sampler were not successful: The Fel d1 content in all samples remained below detection
limits.
The use of Allerpet, indicates that a decrease in the load of Fel d1 in the settled dust of the dwelling will be obtained.
The consequences of an accumulation of Allerpet / Fel d1 complexes in furnishings should be examined further. Whether the
decrease in allergen is sufficient to reduce symptoms in a specific cat allergic person will depend on the dwelling characteristics
and upon the allergic person’s sensitivity.
This study of Allerpet was directed and funded by Bayer AG, Leverkusen, Germany